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By National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

ISBN-10: 0309112982

ISBN-13: 9780309112987

ISBN-10: 0309112990

ISBN-13: 9780309112994

The recent box of toxicogenomics provides a almost certainly robust set of instruments to higher comprehend the overall healthiness results of exposures to toxicants within the setting. on the request of the nationwide Institute of Environmental healthiness Sciences, the nationwide learn Council assembled a committee to spot the advantages of toxicogenomics, the demanding situations to reaching them, and strength techniques to overcoming such demanding situations. The record concludes that knowing the opportunity of toxicogenomics to enhance public health and wellbeing judgements would require a concerted attempt to generate info, utilize current facts, and learn information in new ways--an attempt requiring investment, interagency coordination, and knowledge administration options.

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Extra resources for Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

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New studies using toxicogenomic technologies are published almost daily. 5 Even while this report was being prepared, such changes were observed, and therefore the committee has attempted to provide a snapshot of this rapidly evolving field. This report is the product of the efforts of the entire NRC committee. The report underwent extensive, independent external review overseen by the NRC 5 The value of platforms and software is also evolving rapidly and any discussion of platforms or software should not be considered an endorsement by the committee.

Most of these gene-specific methods work consistently at various genomic locations (that is, they have minimal bias by genomic location) and will be useful for high-resolution analysis of the epigenetic modifications to the genome in toxicogenomic studies. TRANSCRIPTOMIC TECHNOLOGIES Transcriptomics describes the global measurement of mRNA transcripts in a biologic system. This collection of mRNA transcripts represents the transcription of all genes at a point in time. Technologies that allow the simultaneous analysis of thousands of transcripts have made it possible to analyze transcriptomes.

DNA microarray technology can be used to generate large amounts of data at moderate cost but is limited to surveys of genes that are included in the microarray. In this technology (see Box 2-1 and Figure 2-3), a solid matrix surface supports thousands of different, surface-bound DNAs, which are hybridized against a pool of RNA to measure gene expression. A systematic comparison indicates that gene expression measured by oligonucleotide microarrays correlates well with SAGE in transcriptional profiling, particularly for genes expressed at high levels (Kim 2003).

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Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment by National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology


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