Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.) PDF

By Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

ISBN-10: 0723436584

ISBN-13: 9780723436584

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G. side-effect profile). e. nose, lung, skin)  Cytokines, chemokines, and adhesion molecules play a key role in regulating the immune and inflammatory responses during episodes of allergic inflammation  Anti-IgE, leukotriene antagonists, and anti-IL-5 are examples of therapies that have targeted specific pathways associated with allergic inflammation  Acknowledgement The authors acknowledge the contributions of Natalija Novak, Thomas Bieber and Patrick G Holt (Ch. 19; 3rd edition), Catherine M Hawrylowicz, Donald W 31 1 Introduction to mechanisms of allergic disease MacGlashan, Hirohisa Saito, Hans-Uwe Simon, Andrew J Wardlaw (Ch.

TH17 cells and regulatory T cells in primary immunodeficiency diseases. J Allergy Clin Immunol 2009; 123:977–983. Paul WE, Zhu J. How are TH2-type immune responses initiated and amplified? Nat Rev Immunol 2010; 10:225–235. Saenz SA, Taylor BC, Artis D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol Rev 2008; 226:172–190. Stone KD, Prussin C, Metcalfe DD. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 2010; 125:S73-S80.

Examples of chemokine receptors expressed on T-cell subsets include CCR4 and CCR8 on Th2 cells, and CCR5, CXCR3, and CXCR6 on Th1 cells (Fig. 30). CCR3 antagonists and allergic inflammation The CC chemokine receptor CCR3 is expressed on multiple leukocytes important to the allergic inflammatory response including eosinophils, basophils, and activated Th2-type lymphocytes. e. CCR3) to inhibit the actions of multiple CC chemokines on eosinophils and other inflammatory cells. Several small molecule inhibitors of CCR3 are effective in inhibiting eosinophil recruitment in animal models of CCR 5 4 Th1 CXCR 3 8 Th2 6 Th17 4 5 7 Threg 7 Fig.

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Allergy by Fred R.T. Nelson and Carolyn Taliaferro Blauvelt (Auth.)

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